The History of PRP Treatments

Platelet-rich plasma (PRP) therapy is a medical treatment that has gained popularity in recent years due to its potential to promote healing and improve recovery times. However, the history of PRP treatment actually goes back several decades. In this article, we will explore the history of PRP treatment and how it has evolved over time.

The use of platelets for medical purposes can be traced back to the 1970s, when platelet transfusions were used to help treat patients with bleeding disorders. However, it wasn’t until the 1990s that the concept of using platelets to promote healing really began to take off.

In 1995, a team of Italian researchers led by Dr. Giovanni Anitua published a study in which they demonstrated that plasma enriched with platelets could be used to stimulate tissue regeneration in dental patients. This early research paved the way for further exploration of PRP therapy in a variety of medical fields.

Over the next few years, a number of studies were conducted to investigate the use of PRP therapy in treating a wide range of conditions, including musculoskeletal injuries, wound healing, and chronic pain. However, it wasn’t until the early 2000s that PRP therapy began to gain widespread acceptance as a medical treatment.

One of the key drivers behind the growing popularity of PRP therapy was the increasing interest in regenerative medicine. Regenerative medicine is a field of medicine that focuses on developing new treatments and therapies that can stimulate the body’s natural healing processes. PRP therapy fits neatly into this field, as it involves using the patient’s own platelets to promote healing and tissue regeneration.

As interest in regenerative medicine grew, so too did interest in PRP therapy. Today, PRP therapy is used to treat a wide range of conditions, including:

• Musculoskeletal injuries, such as ligament and tendon sprains and tears
• Osteoarthritis and other joint-related conditions
• Wound healing and skin rejuvenation
• Chronic pain and inflammation

In recent years, there has been a growing body of research supporting the use of PRP therapy in these and other medical applications. However, there is still much to learn about the safety and efficacy of PRP therapy, and ongoing research is needed to fully explore the potential of this treatment.

One of the challenges with PRP therapy is that there is still no standardized protocol for preparing and administering the treatment. The exact concentration of platelets, the method of extraction, and the timing of treatment can all vary depending on the specific condition being treated. This lack of standardization has led some critics to question the reliability and reproducibility of PRP therapy, and there is ongoing debate within the medical community about the best practices for using this treatment.

Despite these challenges, PRP therapy continues to be a popular and promising treatment option for many patients. With ongoing research and a growing understanding of how to optimize the treatment protocol, there is no doubt that PRP therapy will continue to play an important role in the field of regenerative medicine for years to come.

References:

1. Anitua E, Andia I, Ardanza B, Nurden P, Nurden AT. Autologous platelets as a source of proteins for healing and tissue regeneration. Thromb Haemost. 2004;91(1):4-15.
2. Mishra A, Pavelko T. Treatment of chronic elbow tendinosis with buffered platelet-rich plasma. Am J Sports Med. 2006;34(11):1774-1778.
3. Alsousou J, Thompson M, Hulley P, Noble A, Willett K. The biology of platelet-rich plasma and its application in trauma and orthopaedic surgery: a review of the
4. Patel S, Dhillon MS, Aggarwal S, Marwaha N, Jain A. Treatment with platelet-rich plasma is more effective than placebo for knee osteoarthritis: a prospective, double-blind, randomized trial. Am J Sports Med. 2013;41(2):356-364.
5. Sundman EA, Cole BJ, Fortier LA. Growth factor and catabolic cytokine concentrations are influenced by the cellular composition of platelet-rich plasma. Am J Sports Med. 2011;39(10):2135-2140.
6. Liu Y, Kalén A, Risto O, Wahlström O. Fibroblast proliferation due to exposure to a platelet concentrate in vitro is pH dependent. Wound Repair Regen. 2002;10(5):336-340.
7. Boswell SG, Schnabel LV, Mohammed HO, et al. Increasing platelet concentrations in leukocyte-reduced platelet-rich plasma decrease collagen gene synthesis in tendons. Am J Sports Med. 2014;42(1):42-49.
8. Castillo TN, Pouliot MA, Kim HJ, et al. Comparison of growth factor and platelet concentration from commercial platelet-rich plasma separation systems. Am J Sports Med. 2011;39(2):266-271.
9. Eppley BL, Woodell JE, Higgins J. Platelet quantification and growth factor analysis from platelet-rich plasma: implications for wound healing. Plast Reconstr Surg. 2004;114(6):1502-1508.
10. Foster TE, Puskas BL, Mandelbaum BR, Gerhardt MB, Rodeo SA. Platelet-rich plasma: from basic science to clinical applications. Am J Sports Med. 2009;37(11):2259-2272.
11. Foster TE, Puskas BL, Mandelbaum BR, et al. Augmentation of tendon healing with platelet-rich plasma and fibrin matrix. Am J Sports Med. 2009;37(10):2028-2037.
12. Sanchez M, Anitua E, Azofra J, et al. Plasma rich in growth factors to treat an articular cartilage avulsion: a case report. Med Sci Sports Exerc. 2003;35(10):1648-1652.
13. Sánchez AR, Sheridan PJ, Kupp LI. Is platelet-rich plasma the perfect enhancement factor? A current review. Int J Oral Maxillofac Implants. 2003;18(1):93-103.
14. Alsousou J, Thompson M, Harrison P, Willett K, Franklin S. Effect of platelet-rich plasma on healing tissues in acute ruptured Achilles tendon: a human immunohistochemistry study. Lancet. 2015;385:S32.